Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
CAS: 720-01-4
Molecular Formula: C8H6ClF3N2O2
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate - Names and Identifiers
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate - Physico-chemical Properties
| Molecular Formula | C8H6ClF3N2O2 |
| Molar Mass | 254.59 |
| Density | 1.45g/ml |
| Melting Point | 36 °C |
| Boling Point | 95 °C |
| Flash Point | 93.292°C |
| Vapor Presure | 0.065mmHg at 25°C |
| pKa | -4.91±0.29(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.466 |
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection |
| HS Code | 29335990 |
| Hazard Note | Irritant |
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate - Introduction
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate, also known as Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate, is an organic compound. Its chemical formula is C7H5ClF3N2O2.
Properties of the compound include:
Appearance: Colorless or light yellow solid
melting point: 70-72 ℃
Boiling point: 235-236 ℃
Density: 1.55g/cm3
Solubility: Soluble in organic solvents such as ethanol, acetone and chloroform
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is mainly used as an intermediate in organic synthesis and can be used to synthesize other organic compounds, such as pesticides, drugs and dyes.
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is generally obtained by a multi-step reaction. First, 4-chloro-2, 5-diaminopyrimidine was synthesized from 2,4-diamino-5-chloropyrimidine. This is then reacted with trifluoromethyl ketone to give 2-trifluoromethyl-4-chloropyrimidine. Finally, 2-trifluoromethyl-4-chloropyrimidine was esterified with ethanol to give Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate.
For safety information, please note the following when handling this compound:
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is an organic compound with certain toxicity. Attention should be paid to avoid contact with skin, eyes and respiratory tract;
-During storage and use, care should be taken to prevent it from reacting with strong oxidants and strong acids;
-Appropriate personal protective equipment such as lab gloves, goggles and face shields should be provided during operation;
-In case of inadvertent contact, immediately flush the affected area with plenty of water and seek medical help;
-When waste is disposed of, it should be disposed of in accordance with local environmental regulations.
Properties of the compound include:
Appearance: Colorless or light yellow solid
melting point: 70-72 ℃
Boiling point: 235-236 ℃
Density: 1.55g/cm3
Solubility: Soluble in organic solvents such as ethanol, acetone and chloroform
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is mainly used as an intermediate in organic synthesis and can be used to synthesize other organic compounds, such as pesticides, drugs and dyes.
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is generally obtained by a multi-step reaction. First, 4-chloro-2, 5-diaminopyrimidine was synthesized from 2,4-diamino-5-chloropyrimidine. This is then reacted with trifluoromethyl ketone to give 2-trifluoromethyl-4-chloropyrimidine. Finally, 2-trifluoromethyl-4-chloropyrimidine was esterified with ethanol to give Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate.
For safety information, please note the following when handling this compound:
- Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate is an organic compound with certain toxicity. Attention should be paid to avoid contact with skin, eyes and respiratory tract;
-During storage and use, care should be taken to prevent it from reacting with strong oxidants and strong acids;
-Appropriate personal protective equipment such as lab gloves, goggles and face shields should be provided during operation;
-In case of inadvertent contact, immediately flush the affected area with plenty of water and seek medical help;
-When waste is disposed of, it should be disposed of in accordance with local environmental regulations.
Last Update：2024-04-09 21:01:54
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Product Name: Ethyl 4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylate Visit Supplier Webpage Request for quotation
CAS: 720-01-4
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Mobile: 18021002903
QQ: 3008007409
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CAS: 720-01-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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